https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29933 15 µmol/L: OR = 2.24; 95% CI = 1.38-3.63) were independently associated with increased risk of cortical cataract. Path analysis showed that the genetic effect on cortical cataract was partially mediated via homocysteine levels. Combined CT/TT genotypes and elevated homocysteine levels were associated with a 3-fold risk of cortical cataract (OR = 3.74; 95% CI = 1.79-7.80). The synergy index of both exposures was 1.34 (95% CI = 0.44-4.01). Conclusions and Relevance: MTHFR polymorphism and elevated homocysteine levels contributed separately and jointly to increased risk of cortical cataract. If these findings are confirmed, homocysteine levels may be a therapeutic target to reduce risk of cortical cataract in persons carrying genetic risk.]]> Wed 10 Nov 2021 15:04:55 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:432 Thu 25 Jul 2013 09:10:00 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43046 6.0 mM (strata-specific OR 1.72, 95% CI 1.09–2.72). No similar association was found in participants with normal FBG (OR 0.85, 95% CI 0.69–1.04). This interaction was not evident in the SEED study. Conclusions: The identified interaction between rs9640883 and FBG in relation to cortical cataract was not replicated but may warrant further investigation.]]> Mon 12 Sep 2022 12:59:35 AEST ]]>